Welcome to the Sivitz Lab
My research interests include the control of cellular energy utilization with emphasis on mitochondrial function as affected by diabetes and obesity. I am also investigating the mechanisms by which mitochondria regulate reactive oxygen production and the relationship of oxygen radicals to the pathophysiology of diabetes and obesity. My laboratory has extensive experience and has generated several publications regarding mitochondrial function in both the isolated organelles and intact cells. I have also carried out investigator initiated clinical research in obesity and diabetes and participate in multi-centered clinical trials as Iowa site PI.
Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II-driven respiration. Fink BD, Bai F, Yu L, Sheldon RD, Sharma A, Taylor EB, Sivitz WI. J Biol Chem. 2018 Nov 1. pii: jbc.RA118.005144. doi: 10.1074/jbc.RA118.005144. [Epub ahead of print]
Effect of a mitochondrial-targeted coenzyme Q analog on pancreatic β-cell function and energetics in high fat fed obese mice. Imai Y, Fink BD, Promes JA, Kulkarni CA, Kerns RJ, Sivitz WI. Pharmacol Res Perspect. 2018 Jun;6(3):e00393. doi: 10.1002/prp2.393. Epub 2018 May 18.
Impact of Excessive Weight Gain on Cardiovascular Outcomes in Type 1 Diabetes: Results From the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study. Purnell JQ, Braffett BH, Zinman B, Gubitosi-Klug RA, Sivitz W, Bantle JP, Ziegler G, Cleary PA, Brunzell JD; DCCT/EDIC Research Group. Diabetes Care. 2017 Nov 14. pii: dc162523. doi: 10.2337/dc16-2523. [Epub ahead of print]
Regulation of ATP production: dependence on calcium concentration and respiratory state. Fink BD, Bai F, Yu L, Sivitz WI. Am J Physiol Cell Physiol. 2017 Aug 1;313(2):C146-C153. doi: 10.1152/ajpcell.00086.2017. Epub 2017 May 17.
Metabolic effects of a mitochondrial-targeted coenzyme Q analog in high fat fed obese mice. Fink BD, Guo DF, Kulkarni CA, Rahmouni K, Kerns RJ, Sivitz WI. Pharmacol Res Perspect. 2017 Mar 10;5(2):e00301. doi: 10.1002/prp2.301. eCollection 2017 Apr.
Impaired utilization of membrane potential by complex II-energized mitochondria of obese, diabetic mice assessed using ADP recycling methodology. Fink BD, Bai F, Yu L, Sivitz WI. Am J Physiol Regul Integr Comp Physiol. 2016 Oct 1;311(4):R756-R763. doi: 10.1152/ajpregu.00232.2016. Epub 2016 Aug 24.
Voltage-Dependent Regulation of Complex II Energized Mitochondrial Oxygen Flux. Bai F, Fink BD, Yu L, Sivitz WI. PLoS One. 2016 May 6;11(5):e0154982. doi: 10.1371/journal.pone.0154982. eCollection 2016.
Evidence for metabolic aberrations in asymptomatic persons with type 2 diabetes after initiation of simvastatin therapy. Suneja M, Fox DK, Fink BD, Herlein JA, Adams CM, Sivitz WI. Transl Res. 2015 Aug;166(2):176-87. doi: 10.1016/j.trsl.2015.01.007. Epub 2015 Jan 28.
Simultaneous quantification of mitochondrial ATP and ROS production. Yu L, Fink BD, Sivitz WI. Methods Mol Biol. 2015;1264:149-59. doi: 10.1007/978-1-4939-2257-4_14.
Human iPS cell-derived insulin producing cells form vascularized organoids under the kidney capsules of diabetic mice. Raikwar SP, Kim EM, Sivitz WI, Allamargot C, Thedens DR, Zavazava N. PLoS One. 2015 Jan 28;10(1):e0116582. doi: 10.1371/journal.pone.0116582. eCollection 2015.